Ultrastructural changes of endothelium associated with thrombocytopenia

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Ultrastructural changes of endothelium associated with thrombocytopenia.

In a study of the relationship between thrombocytopenia and increased vascular fragility, changes in the endothelium of capillaries and postcapillary venules of the tongue were examined by electron microscopy. Adult male albino rabbits (4 kg) were maintained thrombocytopenic (platelets less than 20,000/cu mm) up to 24 hr by one to three injections of guinea pig antirabbit platelet serum. Within...

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Human Thrombocytopenia Is Associated With Structural Abnormalities of the Endothelium

Capillary fragility is characteristic of severe thrombocytopenia. This mechanical weakness may not be solely accounted for by decreased ability of platelets to repair endothelial breaks. Platelets may have a role in maintaining endothelial hemeostasis. This laboratory has demonstrated thinnning of capillary endothelium in experimental thrombocytopenia. We now report similar findings in human th...

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ژورنال

عنوان ژورنال: Blood

سال: 1975

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v46.4.567.567